The ASIP Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human, and Mouse antigen. The ASIP Rabbit pAb Antibody has been validated for the following applications: Immunohistochemistry.
Description
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes